Exeter Chiefs winger Jack Nowell is set to win his third England cap against Ireland in the Six Nations on Saturday.
The 20-year-old has been retained in the England 23-man squad ahead of the match, but Sandy Park colleague Tom Johnson has again been released.
Nowell made his debut earlier this month in the away match against France and also started the 20-0 win against Scotland last time out.
England head coach Stuart Lancaster said: "We feel that the time is right to include George Ford in the matchday squad. A full three weeks of training has allowed him the chance to really understand the way we are developing our game and this time has been crucial in order for him to feel confident and ready in a key decision making and leadership position.
"We have successfully integrated and included many young players over the last two years and George is the next exciting talent to make his mark in the senior squad and we are a looking forward to see him develop over the next few months.
"Brad Barritt is obviously disappointed to miss out but he is still a key member of our squad and I am sure he will get further opportunities in the future. He hasn't had much game time since his injury and will benefit from some time with Saracens over the next two weeks."
England squad, forwards: David Attwood (Bath), Dylan Hartley (Northampton), Joe Launchbury (Wasps), Courtney Lawes (Northampton), Joe Marler (Harlequins), Ben Morgan (Gloucester), Chris Robshaw (Harlequins), Henry Thomas (Sale), Billy Vunipola, Mako Vunipola (both Saracens), David Wilson (Bath), Tom Wood (Northampton), Tom Youngs (Leicester). Backs: Mike Brown (Harlequins), Luther Burrell (Northampton), Danny Care (Harlequins), Lee Dickson (Northampton), Owen Farrell (Saracens), George Ford (Bath), Alex Goode (Saracens), Jonny May (Gloucester), Jack Nowell (Exeter Chiefs), Billy Twelvetrees (Gloucester)